Aquaporin-4 Knockout Exacerbates Corticosterone-Induced Depression by Inhibiting Astrocyte Function and Hippocampal Neurogenesis.

CONCLUSIONS: The present findings suggest AQP4 involves the pathogenesis of depression by modulating astrocytic function and adult neurogenesis, highlighting a novel profile of AQP4 as a potential target for the treatment for depression. PMID: 24422972 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24422972?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - January 15, 2014 Category: Neuroscience Authors: Kong H, Zeng XN, Fan Y, Yuan ST, Ge S, Xie WP, Wang H, Hu G Tags: CNS Neurosci Ther Source Type: research