Elevated Aortic Pulse Wave Velocity Relates to Longitudinal Gray and White Matter Changes

CONCLUSIONS: In older adults, higher baseline aortic PWV related to greater decrease in gray matter volume and greater increase in WMHs over time. Because of unmet cerebral metabolic demands and microvascular remodeling, arterial stiffening may preferentially affect certain highly active brain regions like the temporal lobes. These same regions are affected early in the course of Alzheimer disease.PMID:34706559 | DOI:10.1161/ATVBAHA.121.316477

Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 28, 2021 Category: Cardiology Authors: Corey W Bown Omair A Khan Elizabeth E Moore Dandan Liu Kimberly R Pechman Francis E Cambronero James G Terry Sangeeta Nair L Taylor Davis Katherine A Gifford Bennett A Landman Timothy J Hohman John Jeffrey Carr Angela L Jefferson Source Type: research