Empiric antibiotic therapy in early periprosthetic joint infection: a retrospective cohort study

ConclusionVancomycin combined with ciprofloxacin or a third generation cephalosporin provided the highest antimicrobial coverage of all  responsible pathogens identified in early PJI. Empiric treatment of gram-negative treatment can be safely terminated in the absence of gram-negative pathogens after 4 days of culturing in cases without preoperative antibiotic treatment.
Source: European Journal of Orthopaedic Surgery and Traumatology - Category: Orthopaedics Source Type: research