CSF Findings in Acute NMDAR and LGI1 Antibody-Associated Autoimmune Encephalitis

Discussion
NMDAR-E and LGI-E differ in their typical extent of CSF inflammation. In addition, the patterns formed by the different inflammatory CSF parameters and their relationship with disease severity, age, and disease duration are subtype-characteristic. Moreover, signs for multiple sclerosis-like chronic inflammation are present in a subgroup of patients with NMDAR-E. These CSF patterns might be markers for the different immunopathogeneses of LGI1-E and NMDAR-E.

Source: Neurology Neuroimmunology and Neuroinflammation - October 25, 2021 Category: Neurology Authors: Dürr, M., Nissen, G., Sühs, K.-W., Schwenkenbecher, P., Geis, C., Ringelstein, M., Hartung, H.-P., Friese, M. A., Kaufmann, M., Malter, M. P., Madlener, M., Thaler, F. S., Kümpfel, T., Senel, M., Häusler, M. G., Schneider, Tags: Autoimmune diseases, Encephalitis Article Source Type: research