Endothelial < em > GNAQ < /em > p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels

CONCLUSIONS: Gαq-R183Q, when expressed in ECs, establishes constitutively active PLCβ3 signaling that leads to increased ANGPT2 and a proangiogenic, proinflammatory phenotype. EC-R183Q are sufficient to form enlarged CM-like vessels in mice, and suppression of ANGPT2 prevents the enlargement. Our study provides the first evidence that endothelial Gαq-R183Q is causative for CM and identifies ANGPT2 as a contributor to CM vascular phenotype.PMID:34670408 | DOI:10.1161/ATVBAHA.121.316651

Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 21, 2021 Category: Cardiology Authors: Lan Huang Colette Bichsel Alexis Norris Jeremy Thorpe Jonathan Pevsner Sanda Alexandrescu Anna Pinto David Zurakowski Robin J Kleiman Mustafa Sahin Arin K Greene Joyce Bischoff Source Type: research