Cancers, Vol. 13, Pages 5259: Photodynamic Priming Improves the Anti-Migratory Activity of Prostaglandin E Receptor 4 Antagonist in Cancer Cells In Vitro

This study provides valuable insights into the development of a molecular-targeted photochemical strategy to improve the anti-metastatic effects of EP4 receptor antagonists.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research

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Ovarian carcinosarcoma (OCS) is a rare, highly aggressive and rapidly progressing malignant tumor with an extremely poor prognosis. So far, due to the low incidence of OCS, there are no large-scale prospective studies exploring the standard care of OCS patients. There is no uniform and effective treatment for OCS. Within the development of precision medicine, targeted therapies (such as PARP inhibitors) have been widely used in epithelial ovarian cancer and various other solid tumors. Here, we report a BRCAwt patient with advanced OCS who experienced a second and a third cytoreductive surgery in June 2017 and October 2019 ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Ten percent of women developed BC after EOC. The incidence of BC following EOC in BRCA carriers increases over time, and surveillance is recommended given their enhanced survival of EOC. Timely genetic testing for women with EOC is imperative to better triage BC screening resources and treatment.PMID:34862065 | DOI:10.1016/j.ygyno.2021.10.077
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSIONS: Lowly expressed miR-4282 in EOC specimens is closely linked to the incidence of metastasis and overall survival. MiR-4282 prevents EOC metastasis by a negative regulation on MIER1.PMID:34859847 | DOI:10.26355/eurrev_202111_27232
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Source Type: research
Acta Histochem. 2021 Nov 30;124(1):151821. doi: 10.1016/j.acthis.2021.151821. Online ahead of print.ABSTRACTThe identification of the best reference gene is a critical step to evaluate the relative change in mRNA expression of a target gene by RT-qPCR. In this work, we evaluated nineteen genes of different functional classes using Real Time Human Reference Gene Panel (Roche Applied Sciences), to identify the internal housekeeping genes (HKGs) most suitable for gene expression normalization data in human cell lines. Normal cell lines CCD-19LU (lung fibroblast), HEK-293 (epithelial cell of embryonic kidney), WI-26 VA4 (lung ...
Source: Acta Histochemica - Category: Biochemistry Authors: Source Type: research
CONCLUSIONS: Lowly expressed miR-4282 in EOC specimens is closely linked to the incidence of metastasis and overall survival. MiR-4282 prevents EOC metastasis by a negative regulation on MIER1.PMID:34859847 | DOI:10.26355/eurrev_202111_27232
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSIONS: Non-Hispanic Black women showed a decreased risk of death with the addition of bevacizumab and patients of Asian ancestry had a lower death rate than all other minority groups, but despite these clinically meaningful improvements there was no statistically significant difference in OS among the groups.PMID:34857397 | DOI:10.1016/j.ygyno.2021.11.013
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Source Type: research
Acta Histochem. 2021 Nov 30;124(1):151821. doi: 10.1016/j.acthis.2021.151821. Online ahead of print.ABSTRACTThe identification of the best reference gene is a critical step to evaluate the relative change in mRNA expression of a target gene by RT-qPCR. In this work, we evaluated nineteen genes of different functional classes using Real Time Human Reference Gene Panel (Roche Applied Sciences), to identify the internal housekeeping genes (HKGs) most suitable for gene expression normalization data in human cell lines. Normal cell lines CCD-19LU (lung fibroblast), HEK-293 (epithelial cell of embryonic kidney), WI-26 VA4 (lung ...
Source: Acta Histochemica - Category: Biochemistry Authors: Source Type: research
CONCLUSIONS: Non-Hispanic Black women showed a decreased risk of death with the addition of bevacizumab and patients of Asian ancestry had a lower death rate than all other minority groups, but despite these clinically meaningful improvements there was no statistically significant difference in OS among the groups.PMID:34857397 | DOI:10.1016/j.ygyno.2021.11.013
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Source Type: research
ConclusionsThis is the first study to describe candidate OC variants inFANCI, a member of the ID2 complex of the FA DNA repair pathway. Our data suggest that pathogenicFANCI variants may modify OC risk in cancer families.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research
Gene. 2021 Nov 29:146083. doi: 10.1016/j.gene.2021.146083. Online ahead of print.ABSTRACTNearly three hundred thousand female patients are diagnosed with ovarian cancer in the world annually, and this number shows an increasing trend. However, characteristic symptoms caused by ovarian cancer are so few that early diagnosis remains challenging, and an effective screening method has not yet been established. Here, we conducted a case-control study in Japan to analyze the association between cervicovaginal microbiome and ovarian cancer, using 16S rRNA amplicon sequencing. Analysis of DNA extracted from cervical smear samples ...
Source: Gene - Category: Genetics & Stem Cells Authors: Source Type: research
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