Autoimmune polyendocrine syndrome type 1: an Italian survey on 158 patients

ConclusionsIn Italy, APS-1 is a rare disorder presenting with the three major manifestations and associated with differentAIRE gene mutations. IFN ωAbs are markers of APS-1 and other organ-specific autoantibodies are markers of clinical, subclinical or potential autoimmune conditions.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research

Related Links:

This study provides pilot data for the further development ofL. casei exoproducts as an anti-inflammatory or anti-proliferative agent for the treatment of inflammatory and cancer diseases in gut. However, more data is needed before final conclusions ofL. casei cell-free supernatant ’s efficacy can be drawn.
Source: Inflammation - Category: Allergy & Immunology Source Type: research
AbstractOlea europaea geminivirus (OEGV) from olive accessions in Italy was characterized recently. OEGV was also detected during routine high-throughput sequencing screening of olive (cv. Leccino) material, and its complete bipartite genome segments were sequenced and shown to be 100% identical to those of the isolate from Italy. Using two pairs of newly designed primers targeting the AV1 and BV1 genes, OEGV was detected in randomly sampled olive trees from the U.S. Department of Agriculture National Clonal Germplasm Repository (USDA-NCGR) (21.4% or 6/28), commercial and residential settings in California (47.6% or 10/21)...
Source: Archives of Virology - Category: Virology Source Type: research
AbstractHepatitis E virus (HEV) can infect humans, pigs, and many other animals, but recombination in HEV has rarely been reported. In the present study, phylogenetic and recombination analysis was performed on 557 complete HEV genome sequences from the GenBank database. A potentially significant quadruple recombination event was identified by recombination detection analysis. The recombinant progeny virus, HEV_32_Manchester_301214, was produced by inter-genotype recombination between the major parent HEPAC-44 and the minor parent HE-JA15-1335. HEV_32_Manchester_301214 and HEPAC-44 belong to genotype 3, while HE-JA15-1335 ...
Source: Archives of Virology - Category: Virology Source Type: research
ConclusionSWE allows quantitative assessment of the stiffness of the plantar fascia and can show PFis alterations, increasing the diagnostic performance of B-mode US. In addition, SWE shows a strong correlation with clinical scores, improving patient assessment and follow-up.
Source: Journal of Ultrasound - Category: Radiology Source Type: research
ConclusionsEcho particle velocimetry is safe and feasible for the quantitative assessment of intraventricular flow in patients with an LVAD. The intraventricular LV flow and vortex parameters are severely impaired in these patients.
Source: Journal of Ultrasound - Category: Radiology Source Type: research
ConclusionsWe presented a review of the segmentation and classification methods for tumours detected in BUS images. This review paper selected old and recent studies on segmenting and classifying tumours in BUS images.
Source: Journal of Ultrasound - Category: Radiology Source Type: research
ConclusionAlthough results have to be interpreted with caution due to the large heterogeneity, the superior response rate of TARE and TACE compared to chemo-infusion suggests first choice of TARE or TACE in chemorefractory LMBC patients. Chemo-infusion could be considered in LMBC patients not suitable for TARE or TACE.Level of Evidence3a-
Source: CardioVascular and Interventional Radiology - Category: Radiology Source Type: research
This study attempts to further understand the genetic landscape of cutaneous malignant melanoma in terms of loco-regional variations and malignant potential. Thirty-five cases of cutaneous malignant melanoma were retrieved from the archives and were classified based on location of the primary tumor and presence or absence of metastatic disease. Next-generation sequencing data consisting of base substitutions, copy number variations, indels, and rearrangements in a total of 324 genes were analyzed for recurrent genetic alterations. Statistical analysis was performed using IBM SPSS26 software. Mutations in KDM gene family we...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research
We report the case of a patient with longstanding alopecia universalis and severe atopic dermatitis who presented with diffuse induration and mottled dyspigmentation of his scalp. Multiple scalp biopsies revealed diffuse interfollicular fibroinflammation and IgG4 plasma cells with induction of distinctive dedifferentiated follicles not seen in alopecia areata. This complex case may provide insight into the role of specific subsets of T cells not only in respect to the fibroinflammation linked to IgG4-related diseases but also the capacity to modify disease, follicular stem cell activation, immune privilege, cytotoxicity in...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Extraordinary Case Report Source Type: research
Conclusion: Although a peribulbar lymphocytic infiltrate is the classical finding of AA, it is absent in the chronic phase. Mast cells are commonly found in the scalp biopsy of AA and could explain the potential therapeutic effect of antihistamines.
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Original Study Source Type: research
More News: Addison's Disease | Alopecia | Anemia | Autoimmune Disease | Cancer | Cancer & Oncology | Celiac Disease | Coeliac Disease | Endocrinology | Gallstones | Gastritis | Gastroenterology | Genetics | Hepatitis | Italy Health | Men | Menopause | Pernicious Anemia | Reflex Sympathetic Dystrophy | Vitiligo