Joint Disease Mapping of Breast, Uterine, and Ovarian Cancers in Cities of Isfahan Province from 2005 to 2010 Using Spatial Shared Component Model

Conclusions: Since ovarian and uterine cancers are the less prevalent disease in comparison with breast cancer, the preciseness of these estimates were improved remarkably over simple mapping models. Based on this model, the estimates were done according to the correlation between the diseases. After recognizing the spatial patterns of the shared and specific risk factors and reviewing of previous studies, regardless of risk factors data, environmental pollution arises as a potential risk factor.
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research

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Curr Top Med Chem. 2021 Nov 29. doi: 10.2174/1568026621666211129141631. Online ahead of print.ABSTRACTMedicinal plants have a long history of use as food and remedy in traditional and modern societies, as well as have been used as herbal drugs and sources of novel bioactive compounds. They provide a wide array of chemical compounds, many of which can not be synthesized via current synthesis methods. Natural products may provide aromatase inhibitory activity through various pathways and may act clinically effective for treating pathologies associated with excessive aromatase secretion including breast, ovarian and endometri...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
CONCLUSIONS: We present the findings of a case of leiomyosarcoma in the peritoneum of a female patient with a novel germline splicing variant of RAD51D as potential evidence for the pathogenicity of the variant and its involvement in the risk of sarcoma etiology and/or development. To the best of our knowledge, this is the first case report describing a leiomyosarcoma carrying a germline RAD51D splicing variant and elucidating its pathogenicity on the basis of computational prediction of the impairment of normal transcription and the presumed loss of functional protein production.PMID:34838098 | DOI:10.1186/s13053-021-00205-x
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
Appl Biochem Biotechnol. 2021 Nov 25. doi: 10.1007/s12010-021-03743-1. Online ahead of print.ABSTRACTDifferent metabolic and hormonal disorders like type 2 diabetes mellitus (T2DM), obesity, and polycystic ovary syndrome (PCOS) have tangible socio-economic impact. Prevalence of these metabolic and hormonal disorders is steadily increasing among women. There are clinical evidences that these physiological conditions are related to the manifestation of different gynecological cancers and their poor prognosis. The relationship between metabolic and hormonal disorders with gynecological cancers is quite complex. The need for g...
Source: Applied Biochemistry and Biotechnology - Category: Biochemistry Authors: Source Type: research
World J Clin Cases. 2021 Oct 6;9(28):8349-8357. doi: 10.12998/wjcc.v9.i28.8349.ABSTRACTBACKGROUND: Decreased ovarian reserve function is an ovarian hypofunction disease that occurs in women before 40 years of age, leading to a decline in fertility and perimenopausal symptoms, such as irregular menstruation, amenorrhea, infertility, decreased libido, and autonomic nervous dysfunction. Fenmatong (FMT) is a compound mixture of estradiol tablets and estradiol didroxyprogesterone tablets, which can improve ovarian reserve function by supplementation of exogenous estrogen. However, this treatment has also been shown to cause bre...
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Source Type: research
Pathol Res Pract. 2021 Oct 21;228:153663. doi: 10.1016/j.prp.2021.153663. Online ahead of print.ABSTRACTDOG1 (Discovered on GIST1) is a voltage-gated calcium-activated chloride and bicarbonate channel that is highly expressed in interstitial cells of Cajal and in gastrointestinal stromal tumors (GIST) derived from Cajal cells. To systematically determine in what tumor entities and normal tissue types DOG1 may be further expressed, a tissue microarray (TMA) containing 15,965 samples from 121 different tumor types and subtypes as well as 608 samples of 76 different normal tissue types was analyzed by immunohistochemistry. DO...
Source: Pathology, Research and Practice - Category: Pathology Authors: Source Type: research
J Clin Med. 2021 Sep 18;10(18):4235. doi: 10.3390/jcm10184235.ABSTRACT(1) Background: although most patients with epithelial ovarian cancer (EOC) undergo radical surgery, patients with early-stage disease, borderline ovarian tumor (BOT) or a non-epithelial tumor could be offered fertility-sparing surgery (FSS) depending on histologic subtypes and prognostic factors. (2) Methods: we conducted a systematic review to assess the safety and fertility outcomes of FSS in the treatment of ovarian cancer. We queried the MEDLINE, PubMed, Cochrane Library, and Cochrane ("Cochrane Reviews") databases for articles published i...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Source Type: research
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