Anti-inflammatory efficacy of Berberine Nanomicelle for improvement of cerebral ischemia: formulation, characterization and evaluation in bilateral common carotid artery occlusion rat model

CONCLUSION: Our experimental data show that pretreated groups in different doses (nano BBR 100, 75, 50 mg/kg, and BBR 100 mg/kg) successfully showed decreased levels of the inflammatory factors in cerebral ischemia compared with the stroke group and pretreated group with nano BBR in the dose of 25 mg/kg. Nano BBR formulation with a lower dose can be a better candidate than conventional BBR formulation to reduce oxidative and inflammatory factors in cerebral ischemia. Therefore, BBR-loaded micelle formulation could be a promising protective agent on cerebral ischemia.PMID:34600570 | DOI:10.1186/s40360-021-00525-7

Source: BMC Pharmacology and Toxicology - October 3, 2021 Category: Drugs & Pharmacology Authors: Roza Azadi Seyyedeh Elaheh Mousavi Negar Motakef Kazemi Hasan Yousefi-Manesh Seyed Mahdi Rezayat Mahmoud Reza Jaafari Source Type: research