Phloroglucinol-enhanced whey protein isolate hydrogels with antimicrobial activity for tissue engineering

In this study, WPI hydrogels were enriched with PG at concentrations between 0 and 20% w/v. PG solubilization in WPI hydrogels is far higher than in water. Enrichment with PG did not adversely affect mechanical properties, and endowed antimicrobial activity against a range of bacteria which occur in healthcare-associated infections (HAI). WPI-PG hydrogels supported the growth of, and collagen production by human dental pulp stem cells and - to a lesser extent - of osteosarcoma-derived MG-63 cells. In summary, enrichment of WPI with PG may be a promising strategy to prevent microbial contamination while still promoting stem cell attachment and growth.PMID:34579921 | DOI:10.1016/j.msec.2021.112412

Source: Appl Human Sci - September 28, 2021 Category: Physiology Authors: Varvara Platania Timothy E L Douglas Mikhajlo K Zubko Danny Ward Krzysztof Pietryga Maria Chatzinikolaidou Source Type: research