Issue Information

Front cover:Autism Spectrum Disorder (ASD) is a neurodevelopmental disease originating from combined genetic and environmental factors. Post-mortem human studies and some animal ASD models have shown brain neuroinflammation, oxidative stress and changes in blood brain barrier (BBB) integrity. The balance between Wnt- β-catenin and Shh pathways controls angiogenesis, barriergenesis, neurodevelopment, central nervous system (CNS) morphogenesis and neuronal guidance. These interactions are critical to maintain BBB function in the mature CNS to prevent influx of pathogens and inflammatory cells. Dysregulation of th e Sonic Hedgehog/Wingless-related (Shh-Wnt) pathway mediates neuroinflammation and endothelial injury and may thus lead to Autism Spectrum Disorder (ASD)-characteristic symptoms. In this Review article we explore the role of the Sonic Hedgehog/Wingless-related integration site (Shh/Wnt) pathways in neurodevelopment, neuroinflammation, and BBB development.Read the full article ‘Potential crosstalk between sonic hedgehog-WNT signaling and neurovascular molecules: Implications for blood–brain barrier integrity in autism spectrum disorder’ by E. Gozal, R. Jagadapillai, J. Cai and G. N. Barnes (J. Neurochem. 2021, vol. 159 (1), pp. 15–28) on doi:10.1111/jnc.15460
Source: Journal of Neurochemistry - Category: Neuroscience Tags: Issue Information Source Type: research