Germline Predisposition to Prostate Cancer in Diverse Populations

Urol Clin North Am. 2021 Aug;48(3):411-423. doi: 10.1016/j.ucl.2021.03.008. Epub 2021 Jun 12.ABSTRACTThere remains a paucity of data related to germline genetic alterations predisposing patients to prostate cancer. Recent data suggest that African American, Hispanic, and Asian and Pacific Islander men exhibit genetic alterations in both highly penetrant germline genes, including BRCA1/2, ATM, and CHEK2, and the mismatch repair genes associated with Lynch syndrome, as well as low-penetrant single-nucleotide polymorphisms. However, cohort sizes remain small in many studies limiting the ability to determine clinical significance, appropriate risk stratification, and treatment implications in these diverse populations.PMID:34210495 | DOI:10.1016/j.ucl.2021.03.008

Source: The Urologic Clinics of North America - July 2, 2021 Category: Urology & Nephrology Authors: Kelly K Bree Patrick J Henley Curtis A Pettaway Source Type: research