Paracetamol use during pregnancy - a call for precautionary action

Nat Rev Endocrinol. 2021 Sep 23. doi: 10.1038/s41574-021-00553-7. Online ahead of print.ABSTRACTParacetamol (N-acetyl-p-aminophenol (APAP), otherwise known as acetaminophen) is the active ingredient in more than 600 medications used to relieve mild to moderate pain and reduce fever. APAP is widely used by pregnant women as governmental agencies, including the FDA and EMA, have long considered APAP appropriate for use during pregnancy when used as directed. However, increasing experimental and epidemiological research suggests that prenatal exposure to APAP might alter fetal development, which could increase the risks of some neurodevelopmental, reproductive and urogenital disorders. Here we summarize this evidence and call for precautionary action through a focused research effort and by increasing awareness among health professionals and pregnant women. APAP is an important medication and alternatives for treatment of high fever and severe pain are limited. We recommend that pregnant women should be cautioned at the beginning of pregnancy to: forego APAP unless its use is medically indicated; consult with a physician or pharmacist if they are uncertain whether use is indicated and before using on a long-term basis; and minimize exposure by using the lowest effective dose for the shortest possible time. We suggest specific actions to implement these recommendations. This Consensus Statement reflects our concerns and is currently supported by 91 scientists, clinicians and publ...

Source: Pain Physician - September 24, 2021 Category: Anesthesiology Authors: Ann Z Bauer Shanna H Swan David Kriebel Zeyan Liew Hugh S Taylor Carl-Gustaf Bornehag Anderson M Andrade J ørn Olsen Rigmor H Jensen Rod T Mitchell Niels E Skakkebaek Bernard J égou David M Kristensen Source Type: research