Flunarizine suppresses Mycobacterium tuberculosis growth via calmodulin-dependent phagosome maturation

In conclusion, our results demonstrated that flunarizine enhanced the bactericidal ability of macrophages and clarified its CaM-pCAMKII-dependent mechanism. Therefore, our findings strongly support further studies of this currently approved drug as an HDT candidate for TB therapy.PMID:34533236 | DOI:10.1002/JLB.4A0221-119RR

Source: Journal of Leukocyte Biology - September 17, 2021 Category: Hematology Authors: Siwei Mo Xiaoqian Liu Kehong Zhang Wenfei Wang Yi Cai Qi Ouyang Chuanzhi Zhu Dachuan Lin Haoqiang Wan Dechang Li Zhihua Wen Xinchun Chen Source Type: research