Antihypertensive medication use and ovarian cancer survival

CONCLUSION: Overall, we did not find clear relationships between antihypertensive medication use and ovarian cancer mortality. However, given the limitation of the data, we cannot determine whether the association may differ by type of beta-blockers. The reasons underlying the observed associations with pre-diagnostic calcium-channel blocker use and post-diagnostic ACE inhibitor use require further investigation.PMID:34556331 | DOI:10.1016/j.ygyno.2021.09.009
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Source Type: research

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This study provides valuable insights into the development of a molecular-targeted photochemical strategy to improve the anti-metastatic effects of EP4 receptor antagonists.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
by Camille Mimoun, Xavier Paoletti, Thomas Gaillard, Adrien Crestani, Jean-Louis Benifla, Matthieu Mezzadri, Sofiane Bendifallah, Cyril Touboul, Alexandre Bricou, Yohann Dabi, Geoffroy Canlorbe, Yohan Kerbage, Vincent Lavou é, Lobna Ouldamer, Lise Lecointre, Charles Coutant, Arnaud Fauconnier, Roman Rouzier, Cyrille Huchon ObjectiveThe aim of this study was to develop a new diagnostic tool to predict lymph node metastasis (LNM) in patients with advanced epithelial ovarian cancer undergoing primary cytoreductive surgery. Materials and methodThe FRANCOGYN group ’s multicenter retrospective ovarian cancer cohort ...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
Ihara Ino Nishitsuji High-grade serous ovarian carcinoma (HGSOC) is an epithelial cancer that accounts for most ovarian cancer deaths. Metabolic abnormalities such as extensive aerobic glycolysis and aberrant lipid metabolism are well-known characteristics of cancer cells. Indeed, accumulation of lipid droplets (LDs) in certain types of malignant tumors has been known for more than 50 years. Here, we investigated the correlation between LD accumulation and clinical prognosis. In 96 HGSOC patients, we found that high expression of the LD marker adipophilin was associated with poor progression-free and overall su...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
rid V. Høgdall Ovarian clear cell carcinoma (OCCC) is characterized by dismal prognosis, partially due to its low sensitivity to standard chemotherapy regimen. It is also well-known for presenting unique molecular features in comparison to other epithelial ovarian cancer subtypes. Here, we aim to identify potential subgroups of patients in order to (1) determine their molecular features and (2) characterize their mutational signature. Furthermore, we sought to perform the investigation based on a potentially clinically relevant setting. To that end, we assessed the mutational profile and genomic instability of 5...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conclusions: Tumours from 274 women were sequenced, including high-grade serous carcinoma (n = 252), clear cell carcinoma (n = 4), carcinosarcoma (n = 9), endometrioid carcinoma (n = 3), undifferentiated carcinoma (n = 1), and mixed tumours (n = 5). Genomic profiling did not influence histologic diagnosis. Mutations were identified in TP53, BRCA1, BRCA2, as well as additional homologous recombination repair pathway genes BARD1, ATR, CHEK2, PALB2, RAD51D, RAD50, SLX4, FANCA, RAD51C, and RAD54L. In addition, mutations in PTEN and CDKN2A were identified. Several somatic mutations with implications for germline testing were id...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Schloss Ovarian cancer has the lowest survival rate in gynaecologic malignancies with a 5-year survival rate of 43%. Platinum resistance is one of the main drivers of ovarian cancer mortality, of which aberrant methylation has been cited as a significant contributor. Understanding the essential role of the methylenetetrahydrofolate reductase enzyme (MTHFR) on DNA synthesis and repair, and how nutrient status can vastly affect its performance, led to the investigation of MTHFR status and dietary influence on platinum response in epithelial ovarian cancer (EOC) patients. Twenty-five adult female patients who completed fi...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Environ Pollut. 2021 Oct 14:118370. doi: 10.1016/j.envpol.2021.118370. Online ahead of print.ABSTRACTBenzophenone-1 (BP-1) belongs to personal care product-related contaminants of emerging concern and has been recently reported to induce xenoestrogenic effects. However, the underlying mechanisms leading to the activation of target receptors and subsequent various adverse outcomes remain unclear, which is beneficial to safety and health risk assessment of benzophenone-type ultraviolet filters with their widespread occurrence. Herein, we investigated disrupting effects of BP-1 at environmentally relevant concentrations (10-9...
Source: Environmental Pollution - Category: Environmental Health Authors: Source Type: research
To demonstrate Part II of multi-quadrant robotic assisted pelvic primary cytoreductive surgery for Stage IIIC epithelial ovarian cancer.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Plenary 3: Robotics Source Type: research
To demonstrate Part I of multi-quadrant robotic assisted abdominal primary cytoreductive surgery for Stage IIIC epithelial ovarian cancer.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Plenary 3: Robotics Source Type: research
For platinum-sensitive recurrent epithelial ovarian, primary peritoneal and fallopian-tube cancer, only complete resection of disease may confers a survival benefit of secondary debulking surgery (SDS). We will report a case who underwent laparoscopic high anterior resection (HAR) for management of localized recurrent primary peritoneal carcinoma (PPC).
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: Open Communications 17: Laparoscopy-Variety Source Type: research
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