Clinical Relevance of Gastroesophageal Cancer Associated SNPs for Oncologic Outcome After Curative Surgery

CONCLUSIONS: Two intron variant SNPs of MGMT and STARD3 were identified that were significant survival predictors and may influence tumor biology. The data indicate that DNA methylation (MGMT) and malfunction of GPI anchoring (PGAP3) are distinct mechanisms that are relevant for tumor progression and relapse.PMID:34529172 | DOI:10.1245/s10434-021-10771-y

Source: Ann Oncol - September 16, 2021 Category: Cancer & Oncology Authors: Jin-On Jung Naita Maren Wirsik Henrik Nienh üser Leila Peters Beat Peter M üller-Stich Timo Hess Vitalia Sch üller Johannes Schumacher Thomas Schmidt Source Type: research