Alterations in regulatory T cells and immune checkpoint molecules in pancreatic cancer patients receiving FOLFIRINOX or gemcitabine plus nab-paclitaxel

ConclusionsChemotherapy with FOLFIRNOX or gemcitabine/nab-paclitaxel induces variable changes in circulating T-cell populations that may provide prognostic information in PDAC.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research

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Neoadjuvant chemotherapy (NAC) is being utilized more frequently in patients with pancreatic adenocarcinoma (PDAC). Not all patients can tolerate modern multiagent regimens due to toxicity profiles or pre-existing comorbidities. We utilized institutional data and the National Cancer Database (NCDB) to investigate if the time from diagnosis to NAC start is associated with survival from surgery for PDAC.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Hepatobiliary and Pancreas Source Type: research
Biomaterials. 2021 Oct 9;278:121176. doi: 10.1016/j.biomaterials.2021.121176. Online ahead of print.ABSTRACTAccumulating evidence suggests that stromal modifications improve chemotherapeutic outcomes in pancreatic ductal adenocarcinoma (PDAC). However, combination regimens of stroma-modifying agents and small-molecule cytotoxic drugs have achieved only limited improvements in the clinic, probably due to unsatisfactory pharmacokinetic profiles and restricted drug distribution in tumors. Here, we developed self-assembled prodrug nanoparticles integrating a stromal reprogramming inducer, calcipotriol (CAL), and a potent chemo...
Source: Biomaterials - Category: Materials Science Authors: Source Type: research
Conclusions: RS predicted worse LRR and OS in R-PDAC and worse LRR, DR, and OS in BR/LA-PDAC. This may select patients who would benefit from radiation and should be validated prospectively.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionsThe AGIG chemo-immunotherapy regimen has presented favorable ORR, OS, and manageable toxicities as first-line therapeutic strategy of advanced pancreatic cancer treatment. This regimen may be a novel reliable therapeutic option for patients with preserved performance status. The improvement of treatment efficiency may be related to the activation of non-specific immune response.Clinical Trial Registrationhttps://clinicaltrials.gov/. identifier NCT03768687.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Oncol Lett. 2021 Nov;22(5):809. doi: 10.3892/ol.2021.13070. Epub 2021 Sep 27.ABSTRACTPancreatic cancer has a dire prognosis and will represent the second leading cause of cancer death in the next 10 years. The multifactorial approach represents one of the main issues in controlling the extension of this neoplasm. In recent years, the characteristics of the tumor microenvironment, metastasis mechanisms and the relationship between immune system and neoplastic cells have been described, which has made it possible to understand the pathophysiology of pancreatic adenocarcinoma. Currently, there is a failure to provide an effec...
Source: Oncology Letters - Category: Cancer & Oncology Authors: Source Type: research
Cancer Biol Ther. 2021 Oct 10:1-7. doi: 10.1080/15384047.2021.1980312. Online ahead of print.ABSTRACTBACKGROUND: The technique to analyze circulating tumor DNA (ctDNA) in body fluid (so-called "liquid biopsy") is recently developed.AIMS: Our aim was to assess the utility of liquid biopsy for predicting progression of pancreatic ductal adenocarcinoma (PDAC) after surgical resection or chemotherapy.METHODS: A total of 72 patients with PDAC were retrospectively enrolled for this study, 33 treated surgically and 39 given chemotherapy, either FOLFIRINOX (oxaliplatin/irinotecan/fluorouracil/leucovorin) or gemcitabine p...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Source Type: research
Oncol Lett. 2021 Nov;22(5):809. doi: 10.3892/ol.2021.13070. Epub 2021 Sep 27.ABSTRACTPancreatic cancer has a dire prognosis and will represent the second leading cause of cancer death in the next 10 years. The multifactorial approach represents one of the main issues in controlling the extension of this neoplasm. In recent years, the characteristics of the tumor microenvironment, metastasis mechanisms and the relationship between immune system and neoplastic cells have been described, which has made it possible to understand the pathophysiology of pancreatic adenocarcinoma. Currently, there is a failure to provide an effec...
Source: Oncology Letters - Category: Cancer & Oncology Authors: Source Type: research
Cancer Biol Ther. 2021 Oct 10:1-7. doi: 10.1080/15384047.2021.1980312. Online ahead of print.ABSTRACTBACKGROUND: The technique to analyze circulating tumor DNA (ctDNA) in body fluid (so-called "liquid biopsy") is recently developed.AIMS: Our aim was to assess the utility of liquid biopsy for predicting progression of pancreatic ductal adenocarcinoma (PDAC) after surgical resection or chemotherapy.METHODS: A total of 72 patients with PDAC were retrospectively enrolled for this study, 33 treated surgically and 39 given chemotherapy, either FOLFIRINOX (oxaliplatin/irinotecan/fluorouracil/leucovorin) or gemcitabine p...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Source Type: research
Oncol Lett. 2021 Nov;22(5):809. doi: 10.3892/ol.2021.13070. Epub 2021 Sep 27.ABSTRACTPancreatic cancer has a dire prognosis and will represent the second leading cause of cancer death in the next 10 years. The multifactorial approach represents one of the main issues in controlling the extension of this neoplasm. In recent years, the characteristics of the tumor microenvironment, metastasis mechanisms and the relationship between immune system and neoplastic cells have been described, which has made it possible to understand the pathophysiology of pancreatic adenocarcinoma. Currently, there is a failure to provide an effec...
Source: Oncology Letters - Category: Cancer & Oncology Authors: Source Type: research
Cancer Biol Ther. 2021 Oct 10:1-7. doi: 10.1080/15384047.2021.1980312. Online ahead of print.ABSTRACTBACKGROUND: The technique to analyze circulating tumor DNA (ctDNA) in body fluid (so-called "liquid biopsy") is recently developed.AIMS: Our aim was to assess the utility of liquid biopsy for predicting progression of pancreatic ductal adenocarcinoma (PDAC) after surgical resection or chemotherapy.METHODS: A total of 72 patients with PDAC were retrospectively enrolled for this study, 33 treated surgically and 39 given chemotherapy, either FOLFIRINOX (oxaliplatin/irinotecan/fluorouracil/leucovorin) or gemcitabine p...
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Source Type: research
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