EFhd2 brain interactome reveals its association with different cellular and molecular processes

This study presents, for the first time, an EFhd2 brain interactome that it is associated with different cellular and molecular processes.These findings will help prioritize further studies to investigate the mechanisms by which EFhd2 modulates these processes in physiological and pathological conditions of the nervous system.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research

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In conclusion, mitophagy pathways play an important role in maintaining physiological homeostasis, are involved in the mechanisms of aging and neurodegenerative disorders, and represent promising targets for the development of potential therapeutic agents aimed at regulating mitochondria quality control in neurons and glial cells. A significant number of molecules that induce or inhibit mitophagy are currently under consideration, which may be useful for testing hypotheses or developing drugs for the treatment of neurodegenerative diseases. The validation of promising drugs in animal and cell models, including neurons and ...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Ryan Limbocker, Silvia Errico, Denise Barbut, Tuomas P. J. Knowles, Michele Vendruscolo, Fabrizio Chiti, Michael Zasloff The natural products squalamine and trodusquemine are promising potential therapeutics against Alzheimer's, Parkinson's, and other neurodegenerative diseases for their ability to modulate protein aggregation processes and target protein misfolded oligomers that are toxic to neurons. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Nat. Prod. Rep. latest articles - Category: Chemistry Authors: Source Type: research
Conditions:   OSA;   Sleep Apnea;   Obstructive Sleep Apnea;   Alzheimer Disease Interventions:   Other: Supplemental Oxygen;   Device: Continuous Positive Airway Pressure Machine;   Other: Room Air Sponsor:   University of California, San Diego Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Br J Ophthalmol. 2021 Oct 25:bjophthalmol-2021-319678. doi: 10.1136/bjophthalmol-2021-319678. Online ahead of print.ABSTRACTPURPOSE: To investigate the association of self-reported cataract surgery with all-cause and cause-specific mortality using a large-scale population-based sample.METHODS: Data from the 1999-2008 cycles of the National Health and Nutrition Examination Survey were used. A self-reported history of cataract surgery was considered a surrogate for the presence of clinically significant cataract surgery. Mortality data were ascertained from National Death Index records. Hazard ratios (HRs) and 95% confidence...
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Funding Opportunity RFA-AG-23-001 from the NIH Guide for Grants and Contracts. The goal of this Funding Opportunity Announcement (FOA) is to support research studying the role of bilingualism as it relates to cognitive reserve/resilience in healthy aging and in Alzheimer's disease (AD) and Alzheimer's disease-related dementias(ADRD). This FOA aims to address the need for more prospective, hypothesis-driven research to build a theoretical framework and to clearly identify the extent to which acquiring a second language impacts human brain function. Multimodal and multidisciplinary studies are highly encouraged to improve o...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
AbstractAlzheimer ’s disease (AD) is the foremost type of dementia that afflicts considerable morbidity and mortality in aged population. Several transcription molecules, pathways, and molecular mechanisms such as oxidative stress, inflammation, autophagy, and immune system interact in a multifaceted way that disru pt physiological processes (cell growth, differentiation, survival, lipid and energy metabolism, endocytosis) leading to apoptosis, tauopathy,β-amyloidopathy, neuron, and synapse loss, which play an important role in AD pathophysiology. Despite of stupendous advancements in pathogenic mechanisms, trea...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
ConclusionsThe characterization of three AD mouse models at different disease stages provides an unprecedented view of AD pathology and how this differs from physiological aging. Moreover, our computational strategy to chemically revert AD signatures has shown that NSAID and anti-hypertensive drugs may still have an opportunity as anti-AD agents, challenging previous reports.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research
Background: Mild cognitive impairment (MCI) is an intermediary state between normal aging and dementia. It has a high risk of progression in patients with Alzheimer's disease (AD). Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique used to improve cognitive deficits in patients with MCI and AD. Although previous meta-analyses included studies carried on patients with MCI and AD, few studies have analyzed patients with MCI independently. This meta-analysis aimed to evaluate the effects and safety of rTMS on cognition function in patients with MCI and factors that may influence ...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Findings in mice and people suggest that an FDA-approved drug used for high blood pressure and swelling may alleviate symptoms of Alzheimer ’s disease.
Source: NIH Research Matters from the National Institutes of Health (NIH) - Category: Consumer Health News Source Type: news
Conclusions: This study found the combined drug treatment of somatic diseases, particularly for central nervous, digestive, cardiovascular, respiratory and genitourinary drugs were extremely common among older psychiatric in-patients in China. With increasing age, the F20-F29 patients decreased, while F00-F09 patients increased; the antipsychotics prescriptions decreased, and almost all comorbidity drugs increased. Compared with that in 2005-2010, the older patients with all diagnosis except F20-F29 increased in 2011-2015, and the prescriptions for psychotropic, genitourinary, and cardiovascular drugs increased.
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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