Significance of glutathione peroxidase 4 and intracellular iron level in ovarian cancer cells —“utilization” of ferroptosis mechanism

ConclusionWe demonstrate the significance of GPX4 and intracellular iron level in ovarian cancer cells. Importantly, inhibition of GPX4 interferes with both intracellular iron homeostasis and lipid peroxide reducibility, inducing ferroptosis and exerting anti-cancer effect, which can be a potential effective strategy for ovarian cancer therapy.
Source: Inflammation Research - Category: Research Source Type: research