Genome-wide epigenomic analyses in patients with nociceptive and neuropathic chronic pain subtypes reveals alterations in methylation of genes involved in the neuro-musculoskeletal system

Chronic pain conditions 40 demonstrate complex interactions between biological, psychological, environmental, and social factors, and their etiology and physiopathology remain obscure 19. In 2019, the International Association for the Study of Pain (IASP) defined two main types of pain, nociceptive and neuropathic, and established various criteria for their description. Concerning chronic nociceptive pain (NOCI), the trigger is an activation of the nociceptors, either at the surface of the body (i.e., skin) or at a deeper level (i.e., muscle, bones, joints, or tendons), without damage to the somatosensory nervous system.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research