Efficacy of nikkomycin Z in murine CNS coccidioidomycosis: modelling sustained-release dosing

ConclusionsThis efficacy supports the development of sustained-release nikZ. Decreased intake wouldn ’t be a factor in humans, receiving drug via extended-release pill or continuous IV infusion. In prior studies (twice daily nikZ) of murine coccidioidal meningitis, results were inferior, suggesting sustained release may provide both convenience and superior outcomes.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Source Type: research