Palmitate ‐mediated induction of neuropeptide Y expression occurs through intracellular metabolites and not direct exposure to proinflammatory cytokines

This study suggests that the intracellular metabolism of palmitate and elevation of metabolites, including ceramide and phospholipids, are responsible for the palmitate-mediated induction of the potent orexigenNpy. Furthermore, this suggests that the regulation ofNpy expression is less reliant on inflammatory cytokinesper se than palmitate metabolites in a model of NPY/AgRP neurons. These lipid species likely induce detrimental downstream cellular signalling events ultimately causing an increase in feeding, resulting in an overweight phenotype and/or obesity.

Source: Journal of Neurochemistry - September 6, 2021 Category: Neuroscience Authors: Andy Tran, Wenyuan He, Jim T.C. Chen, Leigh Wellhauser, Kathyrn E. Hopperton, Richard P. Bazinet, Denise D. Belsham Tags: ORIGINAL ARTICLE Source Type: research