Expression Biomarkers of Pharmacological Treatment Outcomes in Women with Unipolar and Bipolar Depression

Conclusion Based on transcriptomic profiling, we identified potential expression biomarkers of treatment outcomes for UD and BD. We also proved that the Ras-GEF pathway associated with long-term memory, female stress response, and treatment response modulation in animal studies impacts treatment efficacy in patients with BD. Further studies focused on the outlined genes may help provide predictive markers of treatment outcomes in UD and BD. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Pharmacopsychiatry - September 1, 2021 Category: Psychiatry Authors: Dmitrzak-Weglarz, Monika Szczepankiewicz, Aleksandra Rybakowski, Janusz Kapelski, Pawe ł Bilska, Karolina Skibinska, Maria Reszka, Edyta Lesicka, Monika Jablonska, Ewa Wieczorek, Edyta Pawlak, Joanna Tags: Original Paper Source Type: research