Interleukin-5 Receptor alpha (CD125) Expression on Human Blood and Lung Neutrophils

CONCLUSION: In addition to expression on eosinophils and basophils, the IL-5Rα is consistently and abundantly expressed on the surface of blood and especially airspace neutrophils. These observations support the concept that some of the efficacy of IL5/IL-5R-targeting biologics observed in asthma may reflect their ability to target neutrophilic airspace inflammation.PMID:34391897 | DOI:10.1016/j.anai.2021.08.004

Source: Annals of Allergy, Asthma and Immunology - August 15, 2021 Category: Allergy & Immunology Authors: Monica G Lawrence W Gerald Teague Xin Feng Caitlin Welch Elaine Etter Julie Negri Marthajoy Spano Kristin Wavell Thomas Braciale John W Steinke Larry Borish Source Type: research