P –732 Maternal over-the-counter analgesics use during pregnancy and adverse perinatal outcomes: cohort study of 151,141 singleton pregnancies

AbstractStudy questionIs in utero exposure to five over-the-counter (non-prescription) analgesics (paracetamol, ibuprofen, aspirin, diclofenac, naproxen) associated with offspring health outcomes?Summary answerConsumption of over-the-counter analgesics during pregnancy, either as single compounds or in combinations, is significantly associated with a variety of adverse offspring health outcomes.What is known alreadyA high percentage of pregnant women use over-the-counter analgesics during pregnancy globally. Some of these compounds such as paracetamol are considered safe to use, while contraindications exist for others, such as NSAIDs use beyond gestational week 30. Current evidence regarding the safety of use during pregnancy in humans is largely conflicting. Results from many published human studies on the topic suffer from limitations including use of small cohorts, short study time or failure to adjust for important confounders. These may explain conflicting results that cause significant concern regarding evidence-based prenatal guidance on use during pregnancy.Study design, size, durationRetrospective cohort study using the Aberdeen Maternity and Neonatal Databank. Data from 151,141 singleton pregnancies over 30 years (between 1985 and 2015) were used. Consumption of paracetamol, ibuprofen, aspirin, diclofenac and naproxen during pregnancy was recorded in medical notes of each woman. In our analysis, the control group was pregnancies where no analgesic was consumed, and...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research