P –775 Obstetric and perinatal outcomes of singleton pregnancies after blastocyst-stage embryo transfer: a systematic review and cumulative meta-analysis

AbstractStudy questionAre obstetric/perinatal outcomes different in singleton pregnancies following blastocyst-stage embryo transfer when compared to cleavage-stage embryo transfer and have results changed over time?Summary answerPregnancies following blastocyst are consistently associated with higher risk of large for gestational age and lower risk of small for gestational age babiesWhat is known alreadyExtended embryo culture to blastocyst-stage is widely used to select best embryos in in vitro fertilisation (IVF) cycles to improve pregnancy rates. Transfer of blastocyst-stage embryos is increasing with this being the default strategy in most clinics. As blastocysts are kept in culture until day 5, 6 or 7 after oocyte fertilisation, there are suggestions that longer exposure to culture media may have a negative impact on pregnancy outcomes. More recent primary studies have challenged some of the initial findings. We therefore conducted an updated systematic review and cumulative meta-analysis (CMA) to examine if these results have changed over time.Study design, size, durationSystematic review of studies published between 1980 and 2020, followed by aggregated meta-analysis and CMA to track the accumulation of evidence over the period of time. Exposed group: singleton pregnancies following blastocyst transfer. Non-exposed group: singleton pregnancies following cleavage-stage transfer. Sub-group analyses were conducted on fresh and frozen-thawed embryo transfers. Perinatal (c...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research

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ConclusionsDietary habits of women became less healthy during the transition from pregnancy to 6  years post-pregnancy. However, results should be interpreted with caution due to the different dietary assessment tools used at the two time points.
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
To compare biventricular and biatrial myocardial strain indices assessed by two-dimensional speckle tracking echocardiography (2D-STE) in women with gestational diabetes mellitus (GDM) and those with uncomplicated pregnancy at the third trimester of pregnancy and in post-partum.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Diabetes in pregnancy is associated with adverse maternal and fetal outcomes including preeclampsia, stillbirth, congenital anomalies and excess fetal growth [1]. Optimisation of maternal blood glucose levels, both before and throughout pregnancy, can improve birth outcomes for women with known diabetes [2]. However, an estimated 92% of diabetes in pregnancy is detected during gestation and classified as either overt diabetes in pregnancy or gestational diabetes mellitus (GDM) [3,4].
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
ta Basu Dietary intakes play an important role in the development of metabolic complications during pregnancy. While reported observational studies reveal an inverse association of healthy diets with weight gain, gestational diabetes, and hypertensive complications during pregnancy, there is a paucity of studies conducted among women of specific ethnicities vulnerable to higher risks of pregnancy complications. This is a secondary cross sectional analysis using baseline data from a previously reported clinical trial. We aim to identify associations of maternal habitual dietary intakes with cardiometabolic risks and inf...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
CONCLUSIONS: Infants of diabetic mothers demonstrate metabolic signs of incomplete beta oxidation and altered lipid metabolism. Infants of mothers with hypertensive disorders of pregnancy carry analyte signals that may reflect oxidative stress via altered nitric oxide signaling. The newborn screen analyte composition is influenced by the presence of these maternal conditions and is further associated with the newborn size designation at birth.IMPACT: Substantial differences in newborn screen analyte profiles were present based on the presence or absence of maternal diabetes or hypertensive disorder of pregnancy and this fi...
Source: Pediatric Research - Category: Pediatrics Authors: Source Type: research
CONCLUSIONS: Our study, which is the largest prospective consecutive cohort to date, has confirmed that advanced maternal age, diabetes, hypertension, obesity, very high social vulnerability, and low socioeconomic status are risk factors of COVID-19-related mortality This article is protected by copyright. All rights reserved.PMID:34672382 | DOI:10.1002/uog.24797
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Source Type: research
CONCLUSIONS: Infants of diabetic mothers demonstrate metabolic signs of incomplete beta oxidation and altered lipid metabolism. Infants of mothers with hypertensive disorders of pregnancy carry analyte signals that may reflect oxidative stress via altered nitric oxide signaling. The newborn screen analyte composition is influenced by the presence of these maternal conditions and is further associated with the newborn size designation at birth.IMPACT: Substantial differences in newborn screen analyte profiles were present based on the presence or absence of maternal diabetes or hypertensive disorder of pregnancy and this fi...
Source: Pediatric Research - Category: Pediatrics Authors: Source Type: research
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Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
ConclusionIn comparison with non-PsA-pregnancies risks of preterm birth and cesarean delivery were mostly increased in those exposed to antirheumatic treatment during pregnancy, especially biologics. As parity influences the risk of preterm birth in PsA pregnancies special attention to first pregnancies is warranted. Women with PsA, should receive individualized monitoring during pregnancy.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: FULL LENGTH Source Type: research
CONCLUSIONS: Despite the scarce data, preexisting DM in pregnancies conceived by ART is associated with increased risk for maternal and neonatal complications.TRIAL REGISTRATION: Registered in PROSPERO (registration number: 143187).PMID:34668169 | DOI:10.1007/s42000-021-00329-8
Source: Hormones - Category: Endocrinology Authors: Source Type: research
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