Extracellular matrix protein laminin β1 regulates pain sensitivity and anxiodepression-like behaviors in mice
This study sheds new light on the functional capability of ECM LAMB1 in modulating pain plasticity and identifies a mechanism that conveys extracellular alterations to intracellular plasticity. Moreover, we identified cingulate LAMB1/integrin β1 signaling as a promising therapeutic target for the treatment of neuropathic pain and associated anxiodepression.
This article reviews the evidence for the treatment of painful-DPN, including emerging treatment strategies, such as novel compounds and stratification of patients according to individual characteristics, (e.g., pain phenotype, neuroimaging, and genotype) to improve treatment responses.PMID:34238163 | DOI:10.2174/1573399817666210707112413
Leprosy is a chronic and progressive disease that primarily affects the skin and peripheral nervous system. Leprosy has been with us for thousands of years. There is evidence of the disease as far back as 4000 BC, in ancient Egypt. In 1873, Norwegian physician Dr. Gerhard Armauer Hansen discovered that leprosy was caused by a bacterium.  Today, we call this bacterium Mycobacterium leprae, and we often refer to leprosy as Hansen’s Disease, in honor of Dr. Hansen. While leprosy caused significant morbidity and mortality in the past, cases today are rare and are curable with proper treatment. How Is Leprosy Transm...
Abstract Patients with diabetic peripheral neuropathy experience debilitating pain that significantly affects their quality of life (Abbott et al., 2011), by causing sleeping disorders, anxiety, and depression (Dermanovic Dobrota et al., 2014). The primary clinical manifestation of painful diabetic neuropathy (PDN) is mechanical hypersensitivity, also known as mechanical allodynia (MA) (Callaghan et al., 2012). MA's underlying mechanism remains poorly understood, and so far, based on symptomatic treatment, it has no effective therapy (Moore et al., 2014). PMID: 32115913 [PubMed - in process]
Conclusions:There was a non-significant increase in age-adjusted mortality with narcolepsy. Close attention should be given to the significantly increased comorbidities of obstructive sleep apnea, low back pain, depression, anxiety, and thyroid disease.Disclosure: Dr. Cohen has nothing to disclose. Dr. Mandrekar has nothing to disclose. Dr. St. Louis has received personal compensation for activities with Axovant, Inc. and Inspire, Inc. Dr. Silber has received royalty payments from UpToDate. Dr. Kotagal has received personal compensation for activities with INC Research. Dr. Kotagal has received royalty payments from UpToDate.
Metformin is Big Pharma's pride and joy when it comes to diabetes. Over 120 million diabetics take this drug to try to control their blood sugar. Even anti-aging doctors have gotten on the bandwagon. They think metformin is a wonder drug. My colleagues keep asking me when I'm going to start prescribing it. Short-term, drugs can be a lifesaver. But long-term, the track record is not so good. Long term, like so many of Big Pharma's "cures," metformin creates more problems than it solves… Patients often stay on this drug for 10 years… 20 years… and more. That's a long time to be ...
Conclusion Similarities in the pregabalin efficacy profiles, including time to onset and magnitude of response, were confirmed regardless of the neuropathic pain condition. These data support the potential for extrapolating analgesic efficacy to other neuropathic pain conditions. ClinicalTrials.gov identifiers NCT00394901, NCT00553475, NCT00407745, NCT00424372, NCT00553280, NCT01202227.
A 42-year-old woman with genetically confirmed but asymptomatic Huntington disease (HD) presented with a 2-year history of tingling along the lateral legs, intermittent band-like sensations in the legs that resolved with walking and worsened during rest, and searing pain from the knee down. She also noticed nocturnal leg jerking on days when she had energy drinks. She had no weakness, lower back pain, or bowel or bladder dysfunction. Family history was notable for HD in her brother and both parents. There was no significant alcohol use or other factors that may have contributed to her symptoms. Neurologic examination showe...