Acute kidney injury in critically Ill children and young adults with suspected SARS-CoV2 infection

CONCLUSIONS: AKI and severe AKI occur commonly in critically ill children with SARS-CoV2 infection, more than double the historical standard. Further investigation is needed during this continuing pandemic to describe and refine the understanding of pediatric AKI epidemiology and outcomes.TRIAL REGISTRATION: NCT01987921.IMPACT: What is the key message of the article? AKI occurs in children exposed to the novel SARS-CoV2 virus at high prevalence (~40% with some form of AKI and 20% with severe AKI). What does it add to the existing literature? Acute kidney injury (AKI) occurs commonly in adult patients with SARS-CoV2 (COVID), very little data describes the epidemiology of AKI in children exposed to the virus. What is the impact? A pediatric vaccine is not available; thus, the pandemic is not over for children. Pediatricians will need to manage significant end-organ ramifications of the novel SARS-CoV2 virus including AKI.PMID:34331019 | DOI:10.1038/s41390-021-01667-4
Source: Pediatric Research - Category: Pediatrics Authors: Source Type: research

Related Links:

This study compared approximately 390,000 people who received the Company’s single-shot COVID-19 vaccine versus approximately 1.52 million unvaccinated people matched on age, sex, time, three-digit zip code, and comorbidities and predictors for COVID-19 infection severity.This study is a longitudinal cohort design, using robust propensity matching methods to create a comparator cohort to assess real-world VE. All analyses were performed using the Aetion Evidence Platform, which is a scientifically validated software that is also used by regulators, payers, and health technology assessment bodies to assess the safety,...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
ejda The proper recruitment of subjects for population-based epidemiological studies is critical to the external validity of the studies and, above all, to the sound and correct interpretation of the findings. Since 2020, the novel coronavirus SARS-CoV-2 pandemic has been a new factor that has been, additionally, hindering studies. Therefore, the aim of our study is to compare demographic, socio-economic, health-related characteristics and the frequency of SARS-CoV-2 infection occurrence among the randomly selected group and the group composed of volunteers. We compare two groups of participants from the cross-sectiona...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
In this study, the antibody response to the RBD of SARS-CoV-2 S protein was analyzed by a panel of sera from animals immunized with RBD-based antigens and four linear B-cell epitope peptides (R345, R405, R450 and R465) were revealed. The immunogenicity of three immunodominant peptides (R345, R405, R465) was further accessed by peptide immunization in mice, and all of them could induced potent antibody response to SARS-CoV-2 S protein, indicating that the three determinants in the RBD were immunogenic. We further generated and characterized monoclonal antibodies (15G9, 12C10 and 10D2) binding to these epitope peptides, and ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The more we understand what SARS-CoV-2 must do to evade our natural immune defenses, the more opportunities we have to create new ways to prevent and treat disease.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Tags: Healthcare /healthcare Innovation /innovation business pharma & Source Type: news
In The Lancet Psychiatry, Dana Tzur Bitan and colleagues present the results of the first longitudinal study assessing COVID-19 outcomes before and after vaccination in a cohort of over 25 000 people with schizophrenia and an equally large sample of matched controls in Israel. Particular strengths of this study are the impressive and well-characterised dataset, and the longitudinal design, allowing exploration of dynamic trends over the course of the first year of the COVID-19 pandemic. From a policy perspective, Israel, where all citizens aged 16 and older gained full access to SARS-CoV-2 vaccination as early as January, ...
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Endocrinology. 2021 Sep 20:bqab203. doi: 10.1210/endocr/bqab203. Online ahead of print.ABSTRACTThe Corona Virus Disease 2019 (COVID-19) pandemic continues to exert a significant impact on global healthcare systems, causing devastating mortality and morbidity. As time passes and our understanding of this novel respiratory virus deepens, it is increasingly clear that its effects extend beyond that of the respiratory system. The coronavirus responsible for COVID-19, SARS-CoV-2, obtains cellular access through the angiotensin converting enzyme 2 (ACE2) receptor in a process requiring the transmembrane serine protease 2 (TMPRSS...
Source: Endocrinology - Category: Endocrinology Authors: Source Type: research
Antimicrob Agents Chemother. 2021 Sep 20:AAC0077221. doi: 10.1128/AAC.00772-21. Online ahead of print.ABSTRACTAntivirals are urgently needed to combat the global SARS-CoV-2/COVID-19 pandemic, supplement existing vaccine efforts, and target emerging SARS-CoV-2 variants of concern. Small molecules that interfere with binding of the viral spike receptor binding domain (RBD) to the host ACE2 receptor may be effective inhibitors of SARS-CoV-2 cell entry. Here we screened 512 pure compounds derived from natural products using a high-throughput RBD/ACE2 binding assay and identified (-)-hopeaphenol, a resveratrol tetramer, in addi...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Source Type: research
ka Since its outbreak in December 2019, the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to an enormous rise in scientific response with an excess of COVID-19-related studies on the pathogenesis and potential therapeutic approaches. Solid organ transplant (SOT) recipients are a heterogeneous population with long-lasting immunosuppression as a joining element. Immunocompromised patients are a vulnerable population with a high risk of severe infections and an increased infection-related mortality rate. It was postulated that the hyperinflammator...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
During the first year and a half of the COVID-19 pandemic, COVAX has been the world ’s most prominent effort to ensure equitable access to SARS-CoV-2 vaccines. Launched as part of the Access to COVID-19 Tools A...
Source: Globalization and Health - Category: International Medicine & Public Health Authors: Tags: Research Source Type: research
AbstractSince 2019, the world was involved with SARS-CoV-2 and consequently, with the announcement by the World Health Organization that COVID-19 was a pandemic, scientific were an effort to obtain the best approach to combat this global dilemma. The best way to prevent the pandemic from spreading further is to use a vaccine against COVID-19. Here, we report the design of a recombinant multi-epitope vaccine against the four proteins spike or crown (S), membrane (M), nucleocapsid (N), and envelope (E) of SARS-CoV-2 using immunoinformatics tools. We evaluated the most antigenic epitopes that bind to HLA class 1 subtypes, alo...
Source: Immunogenetics - Category: Genetics & Stem Cells Source Type: research
More News: Child Development | Children | Epidemiology | History of Medicine | Intensive Care | Pandemics | Pediatrics | SARS | Study | Urology & Nephrology | Vaccines