Upregulation of KLK8 Predicts Poor Prognosis in Pancreatic Cancer

In conclusion, KLK8 overexpression exerts pro-proliferation and anti-apoptotic functions in pancreatic cancer cells via EGF signaling-dependent activation of PI3K/Akt/mTOR pathway. Upregulated KLK8 in PDAC predicts poor prognosis and may be a potential therapeutic target for PDAC.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research