Accelerated expansion of pathogenic mitochondrial DNA heteroplasmies in Huntington’s disease [Genetics]
Mitochondrial dysfunction is found in the brain and peripheral tissues of patients diagnosed with Huntington’s disease (HD), an irreversible neurodegenerative disease of which aging is a major risk factor. Mitochondrial function is encoded by not only nuclear DNA but also DNA within mitochondria (mtDNA). Expansion of mtDNA heteroplasmies (coexistence of...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Yiqin Wang, Xiaoxian Guo, Kaixiong Ye, Michael Orth, Zhenglong Gu Tags: Genetics Biological Sciences Source Type: research
More News: Academies | Brain | Genetics | Huntington's Disease | Mitochondria | Mitochondrial Disease | Neurology | Science