Prognostic role of programmed cell death ligand-1 expression in head and neck cancer treated with programmed cell death protein-1/programmed cell death ligand-1 inhibitors: A meta-analysis based on clinical trials

Conclusions: In summary, PD-L1–positive HNSCC patients portend favorable OS at 6 and 12 months from PD-1/PD-L1 ICIs. Increased ORR also favored to appear in PD-L1 expressors of HNC or recurrent/metastatic HNSCC who received PD-1/PD-L1 ICIs. Therefore, PD-L1 proved to be an appropriate biomarker to predict the clinical efficacy and prognosis of PD-1/PD-L1 ICIs in HNC.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research

Related Links:

In conclusion, our data identified a molecular classifier for high-risk HNSCC as well as other SCC patients, who might benefit from treatment with MEK inhibitors.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
J Pathol Clin Res. 2021 Oct 14. doi: 10.1002/cjp2.244. Online ahead of print.ABSTRACTThe differentiation between a pulmonary metastasis and a newly developed squamous cell carcinoma of the lung in patients with prior head and neck squamous cell carcinoma (HNSCC) is difficult due to a lack of biomarkers but is crucially important for the prognosis and therapy of the affected patient. By using high-resolution mass spectrometry in combination with stable isotope labelling by amino acids in cell culture, we identified 379 proteins that are differentially expressed in squamous cell carcinomas of the lung and the head and neck. ...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
.
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Source Type: research
CONCLUSIONS: In a side-by-side comparison, FGS with uPAR-targeting antibody fragments compared with the parent IgG resulted in earlier tumor visualization at the expense of peak fluorescence intensity.PMID:34642899 | DOI:10.1007/s11307-021-01657-2
Source: Mol Biol Cell - Category: Molecular Biology Authors: Source Type: research
Condition:   Head and Neck Squamous Cell Carcinoma Interventions:   Biological: UV1;   Drug: Sargramostim for Injection;   Drug: Pembrolizumab injection Sponsors:   Martin-Luther-Universität Halle-Wittenberg;   Ultimovacs ASA;   Apotheke der Universitätsmedizin der Johannes Gutenberg-Universität Mainz (Germany);   Axel Hinke. CCRC Cancer Clinical Research Consulting (Düsseldorf, Germany Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionsIn a side-by-side comparison, FGS with uPAR-targeting antibody fragments compared with the parent IgG resulted in earlier tumor visualization at the expense of peak fluorescence intensity.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionFinal sensitivity scores were reasonable but final specificity scores were low. pCLE zones used to calculate specificity were acquired in areas of tumor margins, and the poor quality of the images acquired in these areas explains the final low specificity scores.Clinical relevancePractical adjustments and technical training are needed to analyze head and neck lesions in various anatomical sites in real-time by pCLE.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
Acta Oncol. 2021 Oct 9:1-8. doi: 10.1080/0284186X.2021.1983207. Online ahead of print.ABSTRACTINTRODUCTION: Radiotherapy (RT) for head and neck cancer is now guided by cone-beam computed tomography (CBCT). We aim to identify a CBCT radiomic signature predictive of progression to RT.MATERIAL AND METHODS: A cohort of 93 patients was split into training (n = 60) and testing (n = 33) sets. A total of 88 features were extracted from the gross tumor volume (GTV) on each CBCT. Receiver operating characteristic (ROC) curves were used to determine the power of each feature at each week of treatment to predict progression to radio(c...
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Source Type: research
Oncol Lett. 2021 Nov;22(5):803. doi: 10.3892/ol.2021.13064. Epub 2021 Sep 23.ABSTRACTHead and neck squamous cell carcinoma (HNSCC) has been associated with poor prognosis, due to its strong invasive ability and resistance to chemotherapy. Thus, there is an urgent requirement to identify effective biomarkers for the early diagnosis and prognostic evaluation of HNSCC. COP9 signalosome (COPS) regulates numerous cancer-associated biological processes in various malignancies. The aim of the present study was to investigate the association between COPS and HNSCC. The mRNA expression profiles of COPS in HNSCC were analyzed using ...
Source: Oncology Letters - Category: Cancer & Oncology Authors: Source Type: research
Acta Oncol. 2021 Oct 9:1-8. doi: 10.1080/0284186X.2021.1983207. Online ahead of print.ABSTRACTINTRODUCTION: Radiotherapy (RT) for head and neck cancer is now guided by cone-beam computed tomography (CBCT). We aim to identify a CBCT radiomic signature predictive of progression to RT.MATERIAL AND METHODS: A cohort of 93 patients was split into training (n = 60) and testing (n = 33) sets. A total of 88 features were extracted from the gross tumor volume (GTV) on each CBCT. Receiver operating characteristic (ROC) curves were used to determine the power of each feature at each week of treatment to predict progression to radio(c...
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Clinical Trials | Databases & Libraries | Head and Neck Cancer | HNSCC | Skin Cancer | Squamous Cell Carcinoma | Study