Association Between Specific Childhood Adversities and Symptom Dimensions in People With Psychosis: Systematic Review and Meta-Analysis

AbstractDespite the accepted link between childhood abuse and positive psychotic symptoms, findings between other adversities, such as neglect, and the remaining dimensions in people with psychosis have been inconsistent, with evidence not yet reviewed quantitatively. The aim of this study was to systematically examine quantitatively the association between broadly defined childhood adversity (CA), abuse (sexual/physical/emotional), and neglect (physical/emotional) subtypes, with positive, negative, depressive, manic, and disorganized dimensions in those with psychosis. A search was conducted across EMBASE, MEDLINE, PsychINFO, and Cochrane Libraries using search terms related to psychosis population, CA, and psychopathological dimensions. After reviewing for relevance, data were extracted, synthesized, and meta-analyzed. Forty-seven papers were identified, including 7379 cases across 40 studies examining positive, 37 negative, 20 depressive, 9 disorganized, and 13 manic dimensions. After adjustment for publication bias, general adversity was positively associated with all dimensions (ranging fromr = 0.08 tor = 0.24). Most forms of abuse were associated with depressive (ranging fromr = 0.16 tor = 0.32), positive (ranging fromr = 0.14 tor = 0.16), manic (r = 0.13), and negative dimensions (ranging fromr = 0.05 tor = 0.09), while neglect was only associated with negative (r = 0.13) and depressive dimensions (ranging fromr = 0.16 tor = 0.20). When heterogeneity was found, it tend...
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research