Topographical patterns of whole-brain structural alterations in association with genetic risk, cerebrospinal fluid, positron emission tomography biomarkers of Alzheimer ’s disease, and neuropsychological measures

ConclusionsStrong evidence suggests that atrophy of the AD vulnerable regions is associated with CSF and PET biomarkers and cognitive measures. These relationships may be potentially helpful in characterizing the preclinical and clinical stages of MCI and AD and predicting AD progression.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research

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In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice. To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSION: DeepCEST/deepAREX could rapidly generate accurate CEST/AREX contrasts in animal study. The well-optimized deepCEST/deepAREX have potential for AD differentiation at 3T MRI.PMID:34657318 | DOI:10.1002/mrm.29044
Source: Magnetic Resonance in Medicine - Category: Radiology Authors: Source Type: research
Neurobiol Aging. 2021 Sep 15;109:43-51. doi: 10.1016/j.neurobiolaging.2021.09.010. Online ahead of print.ABSTRACTBrain atrophy occurs in aging even in the absence of dementia, but it is unclear to what extent this is due to undetected preclinical Alzheimer disease. Here we examine a cross-sectional cohort (ages 18-88) free from confounding influence of preclinical Alzheimer disease, as determined by amyloid PET scans and three years of clinical evaluation post-imaging. We determine the regional strength of age-related atrophy using linear modeling of brain volumes and cortical thicknesses with age. Age-related atrophy was ...
Source: Neurobiology of Aging - Category: Geriatrics Authors: Source Type: research
CONCLUSIONS: Off-resonance saturation is an effective way to detect iron in gray matter structures and partially mitigate for the presence of myelin. If a reference region with little iron is available in the tissue, the method can produce quantitative iron maps. This method is applicable in the study of diseases characterized by brain iron accumulation and can complement existing iron-sensitive parametric methods.PMID:34655092 | DOI:10.1002/mrm.29041
Source: Magnetic Resonance in Medicine - Category: Radiology Authors: Source Type: research
Neurobiol Aging. 2021 Sep 15;109:43-51. doi: 10.1016/j.neurobiolaging.2021.09.010. Online ahead of print.ABSTRACTBrain atrophy occurs in aging even in the absence of dementia, but it is unclear to what extent this is due to undetected preclinical Alzheimer disease. Here we examine a cross-sectional cohort (ages 18-88) free from confounding influence of preclinical Alzheimer disease, as determined by amyloid PET scans and three years of clinical evaluation post-imaging. We determine the regional strength of age-related atrophy using linear modeling of brain volumes and cortical thicknesses with age. Age-related atrophy was ...
Source: Neurobiology of Aging - Category: Geriatrics Authors: Source Type: research
CONCLUSION: Conventional visual reading of FDG-PET is moderately accurate in distinguishing between MCI-LB and MCI-AD, and is not significantly improved by univariate single-subject VBA but by a VROI analysis built on macro-regions, allowing for high accuracy independent of reader skills.PMID:34651219 | DOI:10.1007/s00259-021-05568-w
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
DISCUSSION: These findings emphasize that treatments that remove Aβ and completely stop downstream effects on tau and neurodegeneration would only be partially effective in slowing of cognitive decline or reversing cognitive impairment.PMID:34647694 | DOI:10.1002/alz.12480
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Source Type: research
Comput Math Methods Med. 2021 Oct 4;2021:4186666. doi: 10.1155/2021/4186666. eCollection 2021.ABSTRACTAlzheimer's disease (AD) is one of the most important causes of mortality in elderly people, and it is often challenging to use traditional manual procedures when diagnosing a disease in the early stages. The successful implementation of machine learning (ML) techniques has also shown their effectiveness and its reliability as one of the better options for an early diagnosis of AD. But the heterogeneous dimensions and composition of the disease data have undoubtedly made diagnostics more difficult, needing a sufficient mod...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Authors: Source Type: research
DISCUSSION: These findings emphasize that treatments that remove Aβ and completely stop downstream effects on tau and neurodegeneration would only be partially effective in slowing of cognitive decline or reversing cognitive impairment.PMID:34647694 | DOI:10.1002/alz.12480
Source: The Journal of Alzheimers Association - Category: Psychiatry Authors: Source Type: research
The approval of a controversial new drug for Alzheimer’s disease, Aduhelm, is shining a spotlight on mild cognitive impairment — problems with memory, attention, language or other cognitive tasks that exceed changes expected with normal aging. After initially indicating that Aduhelm could be prescribed to anyone with dementia, the Food and Drug Administration now specifies that the prescription drug be given to individuals with mild cognitive impairment or early-stage Alzheimer’s, the groups in which the medication was studied. Yet this narrower recommendation raises questions. What does a diagnosis of mi...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Brain/ Mental Health Aduhelm Alzheimer’s Disease attention-problems brain bleeding brain swelling cognitive problems dementia dementia specialists early-stage Alzheimer’s Food and Drug Administration language problems memory pr Source Type: blogs
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