Circadian rhythms in cardiac metabolic flexibility

Chronobiol Int. 2021 Jun 23:1-14. doi: 10.1080/07420528.2021.1939366. Online ahead of print.ABSTRACTNumerous aspects of cardiovascular physiology (e.g., heart rate, blood pressure) and pathology (e.g., myocardial infarction and sudden cardiac death) exhibit time-of-day-dependency. In association with day-night differences in energetic demand and substrate availability, the healthy heart displays remarkable metabolic flexibility through temporal partitioning of the metabolic fate of common substrates (glucose, lipid, amino acids). The purpose of this review is to highlight the contribution that circadian clocks provide toward 24-hr fluctuations in cardiac metabolism and to discuss whether attenuation and/or augmentation of these metabolic rhythms through adjustment of nutrient intake timing impacts cardiovascular disease development.PMID:34162286 | DOI:10.1080/07420528.2021.1939366

Source: Chronobiology International - June 24, 2021 Category: Biology Authors: Martin E Young Mary N Latimer Source Type: research