C2C12 myoblasts are more sensitive to the toxic effects of simvastatin than myotubes and show impaired proliferation and myotube formation

In conclusion, myoblasts were more susceptible to the toxic effects of simvastatin and simvastatin impaired myoblast proliferation and myotube formation. Impaired muscle regeneration may represent a new mechanism of statin myotoxicity.PMID:34111424 | DOI:10.1016/j.bcp.2021.114649
Source: Biochemical Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research