A Current Amplifier For Local Coil Pre-amplification Of NMR/MRI Signals

A Current Amplifier for Local Coil Pre-amplification of NMR/MRI SignalsDescription of Technology: The magnetic resonance imaging (MRI) systems are used for a variety of imaging application. The present invention discloses an improving MRI device and method by amplifying signals received by resonant NMR coils of MRI systems. It utilizes positive feedback from low-noise Field-Effect Transistor to amplify the signal current that can be coupled out to receiving loops positioned externally without loss in sensitivity. Therefore, the NMR coil can be flexibly positioned near internal tissues and used to develop high-resolution images in highly invasive situations. The disclosed device can be developed in kit form as integrated modules that are designed to be added to tuned NMR receiver coils and tailored to deliver specific gains at NMR frequencies.Potential Commercial Applications: - Medical and scientific research - Device for diagnosticCompetitive Advantages: - Sensitivity - Easy to be integrated into the existed deviceDevelopment Stage: - In vitro data available - In vivo data available (animal)Inventors: Joseph A. Murphy-Boesch, Stephen J. Dodd, Alan P. Koretsky, Chunqi Qian (all of NINDS)Publications: 1. Qian C, et al. Wireless amplified nuclear MR detector (WAND) for high-spatial-resolution MR imaging of internal organs: preclinical demonstration in a rodent model. Radiology. 2013 Jul;268(1):228-36. [PMID 23392428] 2. Qian C, et al. Sensitivity enhancement of remotely coupled...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research