Associations between High-Sensitivity C-Reactive Protein and Non-Communicable Diseases in an Asian Population: Findings from the IFLS Study

Biomarkers. 2021 May 29:1-34. doi: 10.1080/1354750X.2021.1936177. Online ahead of print.ABSTRACTThere has been no comprehensive study on how high-sensitivity C-reactive protein (hs-CRP) level, a biomarker of inflammation, is associated with subsequent diagnoses of various non-communicable diseases (NCDs) in Asians. Our study is the first to do so to better compare these associations in an Asian population. This is a nationwide longitudinal study of 3,410 male and 4,004 female participants of the RAND Indonesian Family Life Survey with a mean age of 42.4 years, to examine associations between increasing hs-CRP levels and risks of heart diseases, stroke, hypertension, diabetes, arthritis, non-cancerous stomach or other digestive diseases, and non-cancerous kidney diseases. We used unadjusted and confounding-adjusted weighted Poisson regression models to respectively examine associations involving hs-CRP as a risk predictor or indicator of chronic inflammation. Several stratified subpopulation analyses were also performed. Increasing hs-CRP levels predicted significantly higher risks of being diagnosed with all of the studied NCDs except stomach or other digestive diseases. After adjusting for confounding, increasing hs-CRP levels were significantly associated with higher risks of diabetes, heart diseases, hypertension, and kidney diseases. Our comprehensive findings on the associations between hs-CRP levels and risks of several NCDs in Asians may have clinical implications and ...
Source: Biomarkers - Category: Research Authors: Source Type: research