Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment

CONCLUSIONS: Metformin protected against CS-induced lung, renal, and muscle injury, mitochondrial dysfunction, and UPR-ER stress in mice. In humans, metformin use was associated with lesser emphysema progression over time. Our results provide a rationale for clinical trials testing the efficacy of metformin in limiting emphysema progression and its systemic consequences.PMID:34033525 | DOI:10.1164/rccm.202012-4510OC

Source: American Journal of Respiratory and Critical Care Medicine - May 25, 2021 Category: Respiratory Medicine Authors: Francesca Polverino Tianshi David Wu Joselyn Rojas-Quintero Xiaoyun Wang Jonathan Mayo Michael Tomchaney Judy Tram Samuel Packard Duo Zhang Kristan H Cleveland Elizabeth Cordoba-Lanus Caroline A Owen Ashraf Fawzy Greg L Kinney Craig P Hersh Nadia N Hansel Source Type: research