Circulating Atrial Natriuretic Peptide Genetic Association Study Identifies a Novel Gene Cluster Associated With Stroke in Whites [Original Articles]

Conclusions— This is the first large-scale genetic association study of circulating NT-proANP levels performed with replication and functional assessment that identified genetic variants in the MTHFR-CLCN6-NPPA-NPPB cluster to be significantly associated with NT-proANP levels. The clinical significance of this variation is related to lower NT-proANP levels, higher blood pressures, and an increased risk of stroke in the general community.
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Tags: Cardio-renal physiology/pathophysiology, Cerebrovascular disease/stroke, Genetics of Stroke, Epidemiology, Genetics of cardiovascular disease Original Articles Source Type: research