Effect of Porphyromonas gingivalis lipopolysaccharide on calcification of human umbilical artery smooth muscle cells co-cultured with human periodontal ligament cells

In conclusion, co-culture with HPDLCs increased the effect of Pg-LPS to stimulate the calcification of HUASMCs. It was suggested that besides the inflammation, periodontitis may promote the occurrence of vascular calcification. The study indicated that periodontal treatment of subgingival scaling to reduce and/or control Porphyromonas gingivalis may decrease the occurrence or severity of vascular calcification.PMID:33968185 | PMC:PMC8097230 | DOI:10.3892/etm.2021.10087
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research

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Conclusion: The current study provides the first evidence regarding the status of frailty in older Chinese adults with hypertension.
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology and risk factors Source Type: research
South Asian ethnicity has been associated with increased cardiovascular risk, in the context of a greater burden of traditional cardiovascular disease risk factors. We aimed to identify the 10-year incidence of coronary heart disease (CHD) in South Asians, as compared to other racial-ethnic groups, in a retrospective cohort study, using the Kaiser Permanente Northern California integrated health care system, and to understand whether traditional risk factors could explain differences in outcomes.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
The protective effect against coronary heart disease that women have for an initial event was not maintained for recurrent CHD events including death, a new study shows.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news
Condition:   Premature Coronary Heart Disease Intervention:   Sponsor:   Chongqing Medical University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract The health benefits and risks of menopausal hormone therapy among women aged 50-59 years are examined in the Women's Health Initiative randomized, placebo-controlled trials using long-term follow-up data and a parsimonious statistical model that leverages data from older participants to increase precision. These trials enrolled 27,347 healthy post-menopausal women aged 50-79 at 40 U.S. clinical centers during 1993-1998, including 10,739 post-hysterectomy participants in a trial of conjugated equine estrogens, and 16,608 participants with uterus in the trial of these estrogens plus medroxyprogesterone acet...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
Cardiovascular diseases (CVDs) are the main cause of mortality worldwide. Risk factors of CVD can be classified into modifiable (smoking, hypertension, diabetes, hypercholesterolemia) through lifestyle changes or taking drug therapy and not modifiable (age, ethnicity, sex and family history). Elevated total cholesterol (TC) and low-density lipoprotein-cholesterol (LDL-C) levels have a lead role in the development of coronary heart disease (CHD), while high levels of high-density lipoprotein-cholesterol (HDL-C) seem to have a protective role. The current treatment for dyslipidemia consists of lifestyle modification or drug...
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Review Source Type: research
Objective To investigate the association between non–high-density lipoprotein cholesterol/apolipoprotein A-I and monocyte/high-density lipoprotein cholesterol ratio and degree of coronary artery stenosis proven by coronary angiography. Methods A total of 1867 patients were enrolled into this study and analyzed retrospectively. Three hundred eighty-five non-coronary artery disease hospitalized patients were selected as control group, 1482 patients diagnosed as coronary artery disease were classified into three subgroups according to the tertiles of their SYNTAX score. We compared the level of non–high-densi...
Source: Coronary Artery Disease - Category: Cardiology Tags: Lipids and Inflammation Source Type: research
It is well known that individuals with type 2 diabetes (T2D) have a higher incidence of heart failure than those without.(1) Less is known, however, about the relationship between impaired glucose tolerance (IGT) and heart failure incidence, and whether treating IGT to delay or prevent development of T2D might reduce the incidence of heart failure. China has one of the highest rates of IGT and new-onset T2D in the world.(2) In addition, the China Heart Survey showed that the prevalence of IGT is significantly higher in individuals with coronary heart disease (CHD), compared with those without CHD.(3) Thus, the combination ...
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
CONCLUSIONS: The extended TPB is an appropriate model to predict medication adherence and provides an effective framework for adherence-enhancing interventions. PMID: 33027135 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Nursing - Category: Nursing Authors: Tags: J Cardiovasc Nurs Source Type: research
Conclusions: Our study provides a novel supramolecular nanomaterial to inhibit pathological progress of atherosclerosis through regulating cholesterol efflux and inflammation, which may contribute to the development of a promising nanomedicine for the treatment of atherosclerosis in the clinic.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
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