Analysis of fentanyl pharmacokinetics, and its sedative effects and tolerance in critically ill children

ConclusionDifferent weight ‐based fentanyl dosing rates may be required for infants and children of different ages to achieve similar plasma concentrations. Using SBS scores may guide the dosing titration of fentanyl that resulted in plasma concentrations within the therapeutic range of 1–3 ng/ml. For those who developed tolerance to fentanyl and/or a sedative, it was noted one day after goal sedation was achieved.

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - April 21, 2021 Category: Drugs & Pharmacology Authors: Sin Yin Lim, Jamie L. Miller, Emilie Henry, Rebecca Heltsley, Sukyung Woo, Peter N. Johnson Tags: ORIGINAL RESEARCH ARTICLE Source Type: research