Comprehensive Gene Expression Analysis Detects Global Reduction of Proteasome Subunits in Schizophrenia

ConclusionsWe detected global down-regulation of proteasome subunits in a subgroup of patients with schizophrenia. We hypothesize that the down-regulation of proteasome subunits leads to proteasome dysfunction that causes accumulation of ubiquitinated proteins, which has been recently detected in a subgroup of schizophrenia patients. Thus, down-regulation of proteasome subunits might define a biological subtype of schizophrenia.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research