Resistance to β-lactams in Streptococcus pneumoniae

Rev Argent Microbiol. 2021 Apr 16:S0325-7541(21)00041-9. doi: 10.1016/j.ram.2021.02.007. Online ahead of print.ABSTRACTStreptococcus pneumoniae is an important causal agent of pneumonia, meningitis, sepsis, bacteremia, and otitis media. Penicillin resistance rates in S. pneumoniae have remained stable in Argentina in the last years. In the late '90s more isolates with MIC of penicillin ≥2μg/ml were observed; however, their frequency has decreased in recent years. The phenotypic expression of penicillin resistance is due to a modification in penicillin-binding proteins associated with a mosaic structure in the coding genes. The expansion of successful resistant clones varies among the different regions and is influenced by the use of antibiotics, vaccines, particularly conjugated ones, as well as population density. Parenteral treatment with high doses of penicillin G continues to be effective for the treatment of pneumonia and bacteremia, oral aminopenicillins for otitis media and sinusitis and third generation cephalosporins for meningitis.PMID:33875295 | DOI:10.1016/j.ram.2021.02.007

Source: Revista Argentina de Microbiologia - April 20, 2021 Category: Microbiology Authors: Martha von Specht Gabriela Garc ía Gabarrot Marta Mollerach Laura Bonofiglio Paula Gagetti Sara Kaufman Laura Vigliarolo In és Toresani Horacio A Lopardo Source Type: research