The effect of probiotics on the expression of Barrett's oesophagus biomarkers.

This study was conducted to evaluate the inhibition effect of probiotics on the expression of biomarkers in in vitro model. Two different Barrett's oesophageal cell lines were selected to co-culture with Bifidobacterium longum and Lactobacillus acidophilus to measure expression of IL18 (interleukin 18), TNFα (tumour necrosis factor-α), p53 (tumour suppressor gene), COX2 (cyclooxygenase 2), and CDX1 (caudal type homeobox 1) genes. In addition, two different aspects of probiotic administration, therapeutic and prophylactic test was also examined. Results showed that microorganisms could inhibit expression of biomarkers, and therapeutic culture condition was more effective than prophylactic test. Obtained results suggest that it is possibility to apply administration of probiotics in BO and OA prevention. PMID: 25666837 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research