PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA for the treatment of pancreatic cancer in vitro and in vivo.

In conclusion, the results from the present study suggest that PLGA/poloxamer nanoparticles loaded with EPAS1 siRNA inhibit pancreatic cancer cell proliferation, induce cell apoptosis under hypoxic conditions and significantly inhibit the formation of microvessels and tumor growth in vivo.
PMID: 25672594 [PubMed - as supplied by publisher]

Source: International Journal of Molecular Medicine - February 11, 2015 Category: Molecular Biology Authors: Pan X, Zhu Q, Sun Y, Li L, Zhu Y, Zhao Z, Zuo J, Fang W, Li K Tags: Int J Mol Med Source Type: research