Fe3O4 < sup > @ < /sup > piroctone olamine magnetic nanoparticles: Synthesize and therapeutic potential in cutaneous leishmaniasis

CONCLUSION: The results of this survey indicated the high potency of Fe3O4@PO NPs to inhibit the growth of amastigote forms of L. major as well as recovery and improvement CL induced by L. major in BALB/c mice without significant cytotoxicity. The results also indicated that, although the possible anti-leishmanial mechanisms of Fe3O4@PO NPs have not been clearly understood, however, the triggering of NO may be considered as one of the possible anti-leishmanial mechanisms of these nanoparticles. However, additional studies, in particular in clinical contexts, are mandatory.PMID:33839494 | DOI:10.1016/j.biopha.2021.111566

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 11, 2021 Category: Drugs & Pharmacology Authors: Aishah E Albalawi Amal Khudair Khalaf Mohamed S Alyousif Abdullah D Alanazi Parastoo Baharvand Mojtaba Shakibaie Hossein Mahmoudvand Source Type: research