Epidemiology, antimicrobial resistance and β-lactamase genotype features of enteropathogenic Escherichia. coli isolated from children with diarrhea in Southern China.

Epidemiology, antimicrobial resistance and β-lactamase genotype features of enteropathogenic Escherichia. coli isolated from children with diarrhea in Southern China. Jpn J Infect Dis. 2015 Jan 20; Authors: Huang Y, Shan XF, Deng H, Huang YJ, Mu XP, Huang AL, Long QX Abstract The main objective of this study was to investigate epidemiology, drug resistance and β-lactamase genotype distribution of enteropathogenic Escherichia. coli (EPEC) isolated from pediatric patients with diarrhea in southern China. The prevalence rate of EPEC in children with diarrhea was 3.53%. O55:K59 and O126:K71 were the main serogroups, and the typical EPEC were more prevalent than atypical EPEC (51 vs 7). Drug resistances to ampicillin and cotrimoxazole were the highest for EPEC isolated from this region, followed by chloramphenicol, ceftriaxone and ceftazidime, respectively. More than 96% of the strains remained susceptible to cefoperazone/sulbactam and imipenem. The most common β-lactamase genotypes identified in 58 strains were blaCTX-M-1 (60.3%), blaTEM (56.9%), blaCTX-M-9 (27.6%), and blaSHV (15.5%). Among 58 isolates, 22 strains were found to harbored one β-lactamase gene, and the resistance to ampicillin, cotrimoxazole, chloramphenicol, ceftriaxone and ceftazidime were 81.8%, 63.6%, 40.9%, 18.2%, and 9.1%, respectively. Other 30 strains carrying multiple β-lactamase genes possessed an increased resistance to the above antimicrobial agents (100%,...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research