Modification of ventriculo –arterial coupling by spironolactone in nonischemic dilated cardiomyopathy

ConclusionsIn NIDCM, adding MRA to conventional anti ‐failure therapy markedly improved LV ejection fraction and reduced peripheral vascular resistance, due to both improved LV contractility and especially to enhanced V–A coupling, as Ea decreased to normal. Total circulatory performance was a sensitive indicator of both LV pump performance and th e arterial loading conditions.

Source: ESC Heart Failure - March 29, 2021 Category: Cardiology Authors: Mark A. Lawson, David E. Hansen, Deepak K. Gupta, Susan P. Bell, Douglas W. Adkisson, Ravinder R. Mallugari, Douglas B. Sawyer, Henry Ooi, Marvin W. Kronenberg Tags: Original Research Article Source Type: research