The Hearts Of Mary Shelley
"Perhaps a corpse would be reanimated... perhaps the components parts of a creature might be manufactured, brought together and endued with vital warmth." -Mary Shelley On Valentine's Day, we consider the heart. The heart is biological; it is the organ on which our life most depends. The heart is emotional, full of love and sorrow. The heart is wandering. No one knew our central muscle's multiple meanings better than Mary Shelley. Mary Shelley was a writer's writer, depressive, miserable, and brilliant. So too the friends she gathered with, at the age of 18, in the spring of 1816 at two adjacent houses on Lake Geneva in Switzerland. The group planned to boat about and adventure, but it was a "wet and ungenial summer," and they instead found themselves contained indoors as the rain pounded on outside. They read aloud from Les Fantasmagoria, a French translation of a German book of horrors, and then Lord Byron, who was present, proposed that they should each compose their own horror story. Mary recused herself from this show of narrative improvisation, at least initially. Then on June 21, 1816, Mary listened to a conversation between Percy Shelley, and Byron and it got her thinking about different sorts of ghosts, those of science and progress. Percy mentioned that the scholar Erasmus Darwin was studying the science necessary to bring dead animals back to life. To Mary, the idea was titillating and horrifying. What would stop scientists from doing it...
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function. On Nutraceutical Senolytics https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/ Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Authors: Corrà U, Piepoli M, Giordano A Abstract Exercise oscillatory ventilation (EOV) is an ominous sign in heart failure due to reduced left ventricular ejection fraction (HFrEF) whatever it is represented. But EOV is detected also in normal healthy individuals and in other cardiovascular disease (CVD) patients, however, its prevalence in these is not completed clear. The aim was to describe the occurrence of EOV in healthy subjects and the overall population all CVD patients who performing symptom limited cardiopulmonary exercise testing (CPET). Healthy subjects were divided in athletes and normal subjec...
Donors of death due to anoxic brain injury such as suicidal hanging are at risk for a severe catecholamine surge leading to an acute myocardial stress that can cause global tissue hypoxia as well as pulmonary edema and barotrauma, all of which may potentially adversely impact myocardial tissue. Concerns have been raised about potential higher rates of Primary Graft Dysfunction (PGD) in heart transplant recipients of such donors due to this acute myocardial stressor. We wanted to assess if this mechanism of donor death does carry an increased risk of PGD or other adverse outcomes in our single center experience.
Cognitive impairment and mood deviation often occurs in patients with heart failure. Frailty and sarcopenia have been widely studied in patients with heart disease, but cognitive frailty has been little explored. High complexity of patients referred for heart transplantation connected with socioeconomic characteristics in a developing country underlines the importance to investigate cognitive and mood conditions in this population. The aim of the study is to evaluate the prevalence of cognitive impairment and depression symptoms in patients with heart failure in waiting list for heart transplantation (HTx).
Burnout is common in all types of physicians, but little is known about burnout in lung transplant physicians. The purpose of this study was to explore burnout and its relationship to job factors and depression in lung transplant physicians.
Left ventricular assist devices (LVAD) are being implanted at a higher rate than ever before to treat end stage heart failure, and are known to decrease mortality and increase quality of life (QOL) for patients. However, major adverse events, including major bleeding and infection (INTERMACS definitions), are common in patients with an LVAD. These events have great potential to impair patient experiences of living with an LVAD.The purpose of this analysis was to examine whether having a major adverse event would alter patient-reported outcomes over time, including depressive symptoms and QOL.
In this study we sought to examine outcomes in recipients stratified by donor brain death related to underlying donor disease vs brain death that was independent of any underlying donor disease (including trauma, suicide, drug overdose, and others).
Severe lung disease may have significant effects on mental health, which may be exacerbated by the stress of awaiting lung transplantation (LTx). However, the prevalence of depression and anxiety symptoms in LTx candidates and the effects of these disorders on health-related quality of life (HRQL) has not been well described. We sought to describe the prevalence of depression and anxiety in patients on the LTx waiting list, and associations between depression or anxiety symptoms and HRQL.
Prior studies suggest an association between elevated depressive symptoms following lung transplant (LT) and mortality. We sought to test this association using a longitudinal cohort with 3-years of follow up, and to determine the long-term impact of LT on depressive symptoms.
Reported outcomes after left ventricular assist device (LVAD) implant include mortality, hospital readmission and severe adverse events. We have less information about patients ’ perceptions of their quality of life (QOL) after hospital discharge. We conducted a prospective two-center international pilot study to assess anxiety, depression and post-traumatic stress disorder (PTSD) following LVAD implant as bridge to transplant (BTT) or destination therapy (DT).