Reply to: Noxious cold stimulation: pro-con perspectives on the hypothermic effect on experimentally evoked cough

In this study we demonstrated that a painful cold stimulus, applied to the hand, inhibited cough responses to capsaicin in humans, and that this phenomenon (known as conditioned pain modulation, CPM) was impaired in patients with refractory chronic cough. Interestingly, the recent study performed by Dong et al. [2] also investigated the effects of cold on the cough reflex. They found placing guinea pigs in a cold environment had the opposite effect, heightening cough responses to cinnamaldehyde in animals repeatedly exposed to citric acid; the citric acid exposure being an attempt to emulate the hyperexcitability of the cough reflex observed in patients with chronic cough.

Source: European Respiratory Journal - March 11, 2021 Category: Respiratory Medicine Authors: Satia, I., Iovoli, E., Holt, K., Woodcock, A. A., Belcher, J., Smith, J. A. Tags: Original Articles: Correspondence Source Type: research